Well it depends on many factors :
The type of files you download
The number of files you have shared and consequently the length of your queues
The time for which you are online
Your connection speed.
I download mostly rare files like speeches and old songs. So the number of people with those type of files is less. So it does not matter to me how much in their queue I am so long as i will be able to download from them. So I put my auto enter queue to 100. But if you are downloading some recent songs or popular ones, then it is a good idea to set your auto enter queues to lower values so that you do not clog other people's queues. Best set it around 20-30 in that case
I presume with that much space, you also have many files.
So it is better that you throttle your uploads so that your downloads are faster.
https://www.winmxworld.com/scripts/bandwidth/is the best place to find out your optimum bandwidth throttles.
Also it will help that you set a lower number of simultaneous uploads so that your queue moves faster.
Limiting the number of downloads may be a good idea also so that you do not end up on someone's ignore list because you hogged his or her queue
It is best that when you find alternates and download one of them then you delete the original file so that it does not remain and become a pain in the a**. It is best to keep not more than 250 incompletes in the winmx incompletes folder. At least when I exceed that number, Winmx crashes and I lose all my running downloads or uploads.
All this is very individual. I suggest that you experiment yourself and see the settings that suit you the best. In case of a mess, it's very easy to revert to your original settings. Pay heed to those warnings too
Hope all this blahblah is useful
Cheers
*Edit (sam) typo