whatever you are using to run windows programs should work just fine with the patch... of course if you're wondering if any windows programs at all run on a mac then the answer is no, nothing at all will - you need to use external programs to run anything (a mac equivalent to wine, think there was a darwine for mac but i'm not sure how well maintained it is so not sure if it works on newer macs).. but if you get winmx to work then the patch should work fine
whatever you use to run it may need a configuration change to use the correct dll file or may work straight off, you'd have to just try and see (wine for example needs the dlloverride set, however the installer detects wine and makes the required change automatically... but it probably wouldn't for other equivalent programs for running windows apps)