TAKEN AT YOUR OWN RISK
Fonts, especially TrueType fonts, use quite a bit of system resources. For optimal performance, trim your fonts down to just those that you need to use on a daily basis and fonts that applications may require.
1. Open Control Panel
2. Open Fonts folder
3. Move fonts you don't need to a temporary directory (e.g. C:FONTBKUP?) just in case you need or want to bring a few of them back. The more fonts you uninstall, the more system resources you will gain.