I am using Wine and WinMx on OpenSuse 11.4 without any problems.
While locked in as a plain user, open YAST, enter the root password, select Software -> Sofware Management. in "Package Listing" type "Wine" .
You will see and select (tick):
The then click on the "Apply" button.
When done, you will find your "C" drive under /home/"your username"/.wine/dosdevices/c:
I never tried sound to work under wine. My PC has no speaker.
Install a Winamp or something like VLC for Windows to test if your sound system is accessible through Wine.